The primary endpoint was ctDNA half-life after radical tumor resection.
Next-generation sequencing-based detection platform was performed to calculate the plasma mutation allele frequency. Plasma samples were obtained at multiple prespecified time points including before surgery (time A), during surgery after tumor resection (time B-time D), and after surgery (time P1-time P3). Experimental Design: Consecutive patients who underwent curative-intent lung resections were enrolled prospectively ( NCT02965391).
This study (DYNAMIC) investigated perioperative dynamic changes in ctDNA and determined the appropriate detection time of ctDNA-based surveillance for surgical patients with lung cancer.
No study has investigated the precise perioperative dynamic changes in circulating tumor DNA (ctDNA) in any patients with early-stage cancer.
